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1 article(s) from Ermer, Franziska

Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo

Alexander Sailer,
Franziska Ermer,
Yvonne Kraus,
Rebekkah Bingham,
Ferdinand H. Lutter,
Julia Ahlfeld and
Oliver Thorn-Seshold

Beilstein J. Org. Chem. 2020, 16, 125–134, doi:10.3762/bjoc.16.14

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Graphical Abstract

Figure 1: a) The potent tubulin inhibitor colchicine as a lead scaffold led to the development of the HOTub g...

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Figure 2: Chemical structures of HITubs. Key variations with respect to HITub-4 are highlighted in dashed box...

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Figure 3: Photocharacterisation of HITub-4. a) Photochemical and thermal isomerisation. b) UV–vis spectra aft...

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Figure 4: a) Resazurin reduction assay for HITub-4 and nocodazole in HeLa cells (n = 3), demonstrating the di...

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Figure 5: Confocal microscopy images of immunofluorescently labelled MT networks after treatment with HITubs ...

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Figure 6: Cell cycle analysis of HITub-4-treated cells. a) and b) (Z)-HITub-4 caused significant G2/M arrest ...

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Full Research Paper

Published 27 Jan 2020

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